ABSTRACT
ObjectiveThere are many kinds of intestinal cleansing drugs in clinical practice at present, but there is no universal and effective intestinal cleansing program. In this study, sodium polyacrylate was used as a candidate drug for intestinal preparation to explore its feasibility, efficacy and safety for intestinal preparation in mice.Methods24 mice fasted for 12 hours were divided, with random number table method, into 4 groups (6 mice in each): blank group, sodium phosphate group, polyethylene glycol group and sodium polyacrylate solution group. Except that the blank group was given isotonic saline (0.6mL/20g) to fill the stomach, the other groups were given sodium phosphate (0.5mL/20g), polyethylene glycol(0.6mL/20g) and sodium polyacrylate solution (0.6mL/20g) to fill the stomach, and the small intestinal propulsion (carbon powder propulsion), the defecation and intestine volume in mice were observed to explore the effect of sodium polyacrylate on the mice colon cleansing.ResultsAfter administration by gavage for 15min, compared with the blank group [(62.72±6.58) %] and the sodium phosphate group [(66.40±9.53) %], the carbon powder propulsion rate of the sodium polyacrylate solution group [(81.17±4.75) %] significantly increased (P<0.05). The number of fecal excretion [(11.5±2.4) granules] in the sodium polyacrylate solution group after 2 hours of gavage was significantly higher than that in the blank group [(4.5±1.0) granules], the sodium phosphate group [(6.2±2.0) granules] and the polyethylene glycol group [(8.5±1.0) granules] (P<0.05). Compared with the blank group [(39.7±11.60) mg] and the sodium phosphate group [(77.2±15.91) mg], the defecation quality of sodium polyacrylate solution [(162.4±16.69) mg] significantly increased within 2h after gavage (P<0.05). Compared with the blank group [(2.25±0.29)g], the sodium phosphate group [(2.72±0.24)g] and the polyethylene glycol group [(2.95±0.19)g], the intestinal mass of the sodium polyacrylate solution group [(3.30±0.16)g] significantly increased (P<0.05).ConclusionOral administration of sodium polyacrylate solution can accelerate intestinal peristalsis in normal mice, promote defecation in mice, and significantly reduce intestinal absorption of water. As a potential intestinal preparation drug, it has the advantages of small dose, high efficiency, safety and reliability.